The earthquake killed approximately 250,000 people. 9. It was the 3rd deadliest earthquake of all time. EARTHQUAKES IN HISTORY: First recorded earthquake: Antioch, southwest Turkey, May 20, 526. This earthquake took a estimated total of 250,000 deaths. The quake caused the port of Seleucia Pieria to rise up by nearly one meter, resulting in the silting of the harbor. The earthquake was followed by a fire that destroyed most of the buildings left standing by the earthquake. Both quakes caused severe damage to the ancient city. Antioch Earthquake, Turkey (526) ... Dysentery and other diseases in the water killed thousands more, and while thereâs no official death toll, estimates range from 2-3 million. 526 Antioch Earthquake. The quake caused the port of Seleucia Pieria to rise up by nearly one meter, resulting in the silting of the harbor. The death toll was a massive 250,000. 526 Antioch Earthquake is the fourth deadliest earthquake with most deaths in the history. This earthquake amassed an unbelievable death toll in a short period. Antioch Earthquake â Syria and Antioch, 526 AD Death Toll: 250,000. This region was part of the Byzantine Empire at that time. 4. It struck during late May, probably between May 20â29, at mid-morning, killing approximately 250,000 people. This region was part of the Byzantine Empire at that time. A deadly earthquake struck Syria and Antioch in the year 526 AD. The earthquake was followed by a subsequent fire, which destroyed the buildings which had managed to survive the earthquake. In late May, 526 AD, an earthquake struck in Syria and Antioch, which were then part of the Byzantine empire. 4. The 526 Antioch earthquake hit Syria (region) and Antioch in the Byzantine Empire in 526. It occurred in May 21, 526. This earthquake amassed an unbelievable death toll in a short period. 4. It struck during late May, probably between May 20-29, at mid-morning, causing severe damage to many of the buildings in Antioch and killing approximately ⦠526 Antioch Earthquake â 250,000 Lives Lost. In late May, 526 AD, an earthquake struck in Syria and Antioch, which were then part of the Byzantine empire. The 526 Antioch earthquake, the fourth known deadliest earthquake to ever strike the world, occurred probably between May 20 to 29 in Syria and Antioch which were then part of the Byzantine Empire. It was the 3rd deadliest earthquake of all time. 526 Antioch earthquake. The death toll was a massive 250,000. Death toll: around 250,000-300,000. A deadly earthquake struck Syria and Antioch in the year 526 AD. The 526 Antioch earthquake hit Syria (region) and Antioch in the Byzantine Empire. The second mention on the top five list, a further earthquake hit Antioch in May 526, and killed somewhere between 250,000 â 300,000 people. 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