Give yourself a few minutes before trying again. So if you are going to dissolve a pill in water, I would recommend you dissolve the pill in about a 1/4 glass of water and drink down soon after. Can I dissolve Benadryl from pills in water effectively? New OxyContin pills harder to break Formula makes it difficult to crush and dissolve. Mix it into the water very well, at this point you can begin filtering it or you can heat it up to help dissolve the oxycodone. That will allow you to cut by smaller increments. In these pills, it is not a good idea to dissolve or crush them as it messes up their function, but is probably not dangerous. Heat is not necessary because oxycodone is. I plan to crush them up, mix then with water, filter out the pill gunk, and if there's too much water to inject I can evaporate some of the water, or maybe boil it and hope the Diphenhydramine doesn't degrade. Such as a supplement for dairy. I'd expect the Diphenhydramine HCL to readily dissolve from the pills into water. Long acting medications need to be taken whole, but medications that are meant to dissolve immediately in the stomach can be dissolved in water then drank. Caution dissolving: Ask your doctor if your medication comes in a liquid or concentrate form. Check before you liquefy. You can also use a pill crusher or mortar and pestle to turn a pill, or part of a pill, into a powder that can be taken with food or in a drink. 2. Some pills can be crumbled and taken with apple sauce, pudding or ice cream. But although some pills may dissolve in water, that may mean that they lose their chemical structure. And you could do that any time, without having to wait until you're down to smaller dose pills. You can also dissolve the pill in more water, which would effectively do the same thing. If you gag or feel like you can’t swallow, carefully remove the pill and dry it off with a paper towel so it doesn’t dissolve. And when you get to 10 mg you can do what you're doing and end up with 0.5 mg per mL. Can I dissolve the iron tablets in water to make them easier to take, or will that weaken or negate the effect of the iron? From antibiotics to painkillers, some pills are so big they’re difficult to swallow, but is it safe to crush or dissolve them? We ask the experts. Still, your point goes to exactly why capsules especially people should use great caution, and that uncoated pills you can pretty safely bet it’s fine to mash it up or dissolve it, just need to make sure it’s ok with food if you mash it in food. Many people that can't swallow pills have to do this. However, a couple of preparations are enteric coated or have timed releases, meaning the coating is meant to not dissolve until the medicine reaches the intestines. It depends on the medication. Other medications don't dissolve well in water and will just sit there. Some long-acting medications are not effective if broken or dissolved. 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